A1 Refereed original research article in a scientific journal
Segregation analysis of mandibular prognathism in Libya
Authors: El-Gheriani AA, Maher BS, El-Gheriani AS, Sciote JJ, Abu-Shahba FA, Al-Azemi R, Marazita ML
Publication year: 2003
Journal: Journal of Dental Research
Journal name in source: Journal of dental research
Journal acronym: J Dent Res
Volume: 82
Issue: 7
First page : 523
Last page: 7
Number of pages: 5
ISSN: 0022-0345
DOI: https://doi.org/10.1177/154405910308200707
Abstract
The etiology of mandibular prognathism has been attributed to various genetic inheritance patterns and some environmental factors. The variation in inheritance patterns can be partly due to the use of different statistical approaches in the respective studies. The objective of this study was to investigate the role of genetic influences in the etiology of this trait. We performed segregation analysis on 37 families of patients currently being treated for mandibular prognathism. Mandibular prognathism was treated as a qualitative trait, with cephalometric radiographs, dental models, and photographs used to verify diagnosis. Segregation analysis of a prognathic mandible in the entire dataset supported a transmissible Mendelian major effect, with a dominant mode of inheritance determined to be the most parsimonious.
The etiology of mandibular prognathism has been attributed to various genetic inheritance patterns and some environmental factors. The variation in inheritance patterns can be partly due to the use of different statistical approaches in the respective studies. The objective of this study was to investigate the role of genetic influences in the etiology of this trait. We performed segregation analysis on 37 families of patients currently being treated for mandibular prognathism. Mandibular prognathism was treated as a qualitative trait, with cephalometric radiographs, dental models, and photographs used to verify diagnosis. Segregation analysis of a prognathic mandible in the entire dataset supported a transmissible Mendelian major effect, with a dominant mode of inheritance determined to be the most parsimonious.
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