Refereed journal article or data article (A1)

A Semiphysiological Population Pharmacokinetic Model for Dynamic Inhibition of Liver and Gut Wall Cytochrome P450 3A by Voriconazole




List of AuthorsFrechen S, Junge L, Saari TI, Suleiman AA, Rokitta D, Neuvonen PJ, Olkkola KT, Fuhr U

PublisherADIS INT LTD

Publication year2013

JournalClinical Pharmacokinetics

Journal name in sourceCLINICAL PHARMACOKINETICS

Journal acronymCLIN PHARMACOKINET

Number in series9

Volume number52

Issue number9

Start page763

End page781

Number of pages19

ISSN0312-5963

DOIhttp://dx.doi.org/10.1007/s40262-013-0070-9


Abstract
The proposed semiphysiological modelling approach generated a mechanistic description of the complex DDI occurring at major CYP3A expression sites and thus may serve as a powerful tool to maximise information acquired from clinical DDI studies. The model has been shown to draw precise and accurate predictions. Therefore, simulations based on this kind of models may be used for various clinical scenarios to improve pharmacotherapy.


Last updated on 2021-24-06 at 11:40