A1 Refereed original research article in a scientific journal
Quantitative evaluation of neutral amino acid transport in cerebral gliomas using positron emission tomography and fluorine-18 fluorophenylalanine
Authors: Ogawa T, Miura S, Murakami M, Iida H, Hatazawa J, Inugami A, Kanno I, Yasui N, Sasajima T, Uemura K
Publisher: SPRINGER VERLAG
Publication year: 1996
Journal: European Journal of Nuclear Medicine
Journal name in source: EUROPEAN JOURNAL OF NUCLEAR MEDICINE
Journal acronym: EUR J NUCL MED
Volume: 23
Issue: 8
First page : 889
Last page: 895
Number of pages: 7
ISSN: 0340-6997
DOI: https://doi.org/10.1007/BF01084361
Abstract
To elucidate the mechanism of large neutral amino acid (LNAA) transport in cerebral gliomas and to evaluate the clinical usefulness of positron emission tomography (PET) with fluorine-18 fluorophenylalanine (F-18-Phe), we examined 18 patients with cerebral glioma using dynamic PET and F-18-Phe, By employing two-compartment model analysis, the influx rate K-1, the efflux rate k(2) and the distribution volume (V-d) Of F-18-Phe were estimated in tumour tissue and contralateral normal grey matter. F-18-Phe showed increased accumulation in tumour tissue regardless of the grade of malignancy in all patients, The rate of uptake of F-18-Phe in high-grade glioma was significantly higher than in low-grade glioma (P < 0.05). However, it was difficult to evaluate the tumour grade only from the F-18-Phe accumulation in individual cases. Values of K-1 and V-d were significantly increased in the tumour tissue. The K-1 value of the tumour tissue tended to decrease with increasing LNAA concentration in plasma, Therefore, influx of F-18-Phe into tumour tissue is mainly related to the carrier-mediated active transport. It is concluded that PET with F-18-Phe is of clinical value for tumour detection rather than assessment of tumour malignancy.
To elucidate the mechanism of large neutral amino acid (LNAA) transport in cerebral gliomas and to evaluate the clinical usefulness of positron emission tomography (PET) with fluorine-18 fluorophenylalanine (F-18-Phe), we examined 18 patients with cerebral glioma using dynamic PET and F-18-Phe, By employing two-compartment model analysis, the influx rate K-1, the efflux rate k(2) and the distribution volume (V-d) Of F-18-Phe were estimated in tumour tissue and contralateral normal grey matter. F-18-Phe showed increased accumulation in tumour tissue regardless of the grade of malignancy in all patients, The rate of uptake of F-18-Phe in high-grade glioma was significantly higher than in low-grade glioma (P < 0.05). However, it was difficult to evaluate the tumour grade only from the F-18-Phe accumulation in individual cases. Values of K-1 and V-d were significantly increased in the tumour tissue. The K-1 value of the tumour tissue tended to decrease with increasing LNAA concentration in plasma, Therefore, influx of F-18-Phe into tumour tissue is mainly related to the carrier-mediated active transport. It is concluded that PET with F-18-Phe is of clinical value for tumour detection rather than assessment of tumour malignancy.
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