A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Blockage of Collagen Binding to Integrin alpha2beta1: Structure-activity Relationships of Protein-protein Interaction Inhibitors
Tekijät: Koivunen JT, Nissinen L, Juhakoski A, Pihlavisto M, Marjamäki A, Huuskonen J, Pentikäinen OT
Julkaisuvuosi: 2011
Journal: MedChemComm
Vuosikerta: 2
Aloitussivu: 764
Lopetussivu: 770
The interaction between the alpha2beta1
integrin and collagen plays a crucial role in the development of pathological
conditions, such as thrombus formation and cancer cell metastasis. Accordingly,
the alpha2beta1 integrin is a promising target for the development of new drug
molecules to treat these diseases. Here, we have designed, synthesized, and
measured in vitro a set of novel drug-like compounds that block the protein–protein
interactions between alpha2beta1 integrin and collagen. The obtained
structure–activity relationship reveals the key features that are required for
successful inhibition of this integrin–collagen interaction.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
