Population-based mammography screening results in substantial savings in treatment costs for fatal breast cancer.

: Kauhava, Immonen-Räihä, Parvinen, Holli, Kronqvist, Pylkkänen, Helenius, Kaljonen, Räsänen, Klemi

: 2006

: Breast Cancer Research and Treatment

: Breast cancer research and treatment

: Breast Cancer Res Treat

: 98

: 2

: 143

: 50

: 8

: 0167-6806

DOI: https://doi.org/10.1007/s10549-005-9142-3

The aim was to assess the effect of population-based mammography screening on treatment costs for fatal breast cancer in Turku, Finland.\nThe study included 556 women with invasive breast cancer, diagnosed at the age of 40-74 years in 1987-1993: 427 in the screened group (screen-detected or interval cancer) and 129 in the unscreened group (not yet invited or refused screening). Both groups were followed up for 8 years from diagnosis.\nIn the unscreened group, 32 (25%) patients died of breast cancer versus 49 (12%) in the screened group (p < 0.001). The non-discounted mean treatment costs were 2.8-fold for those dying of breast cancer compared to survivors: 26,222 euros versus 9,434 euros; the difference between means was 16,788 euros (95% CI 14,915-18,660) (p<0.001). The mean costs for fatal cases were high, irrespective of the way cancer was detected: 23,800 euros in the unscreened group versus 27,803 euros in the screened group; the difference between means was -4,003 euros (-10,810 to 2802) (p=0.245). In the unscreened group, patients with fatal breast cancer accounted for 41% (0.76/1.87 million euros) of the total treatment costs versus 29% (1.36/4.76 million euros) in the screened group. It was estimated that about one third of costs for fatal breast cancer were avoided through mammography screening, accounting for 72-81% of the estimated total treatment cost savings achieved by screening. About 31-35% of the screening costs for 1987 to 1993 were offset by savings in treatment costs.\nTreatment costs for fatal breast cancer are high. Mammography screening results in substantial treatment cost savings, in which reduction of fatal disease is the key element.\nAIMS\nMATERIALS AND METHODS\nRESULTS\nCONCLUSIONS