A2 Refereed review article in a scientific journal
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
Authors: Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bezard, Greg M. Pastores, David C. Rubinsztein, Ralph A. Nixon, Michael R. Duchen, Giovanna R. Mallucci, Guido Kroemer, Beth Levine, Eeva-Liisa Eskelinen, Fanny Mochel, Michael Spedding, Caroline Louis, Olivier R. Martin, Mark J. Millan
Publisher: NATURE PUBLISHING GROUP
Publication year: 2018
Journal: Nature Reviews Drug Discovery
Journal name in source: NATURE REVIEWS DRUG DISCOVERY
Journal acronym: NAT REV DRUG DISCOV
Volume: 17
Issue: 9
First page : 660
Last page: 688
Number of pages: 29
ISSN: 1474-1776
eISSN: 1474-1784
DOI: https://doi.org/10.1038/nrd.2018.109
Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. They are often called 'proteinopathies' owing to the presence of misfolded and aggregated proteins that lose their physiological roles and acquire neurotoxic properties. One reason underlying the accumulation and spread of oligomeric forms of neurotoxic proteins is insufficient clearance by the autophagic-lysosomal network. Several other clearance pathways are also compromised in NDAs: chaperone-mediated autophagy, the ubiquitin-proteasome system, extracellular clearance by proteases and extrusion into the circulation via the blood-brain barrier and glymphatic system. This article focuses on emerging mechanisms for promoting the clearance of neurotoxic proteins, a strategy that may curtail the onset and slow the progression of NDAs.
