Mechanism of pH-independent cleavage and isomerization of 3 '-ribonucleotide phosphodiesters

: Kosonen M, Lonnberg H

Publisher: MARCEL DEKKER INC

: 1999

Nucleosides & nucleotides

NUCLEOSIDES & NUCLEOTIDES

: NUCLEOS NUCLEOT

: 18

: 4-5

: 1099

: 1100

: 2

: 0732-8311

DOI: https://doi.org/10.1080/15257779908041658

The detailed mechanisms of pH-independent cleavage and isomerization reactions of the phosphodiester bond are evaluated by examining kinetics of hydrolytic reactions of selected mono- and dialkyl esters of 3'-uridylic acid. The mechanistic choices are made by comparing LFER's between reaction rates and acidity of the alkyl group of phosphodi- and triesters.

Chemical sciences