A1 Refereed original research article in a scientific journal
Allopurinol does not increase free radical scavenging capacity during reperfusion in coronary artery bypass graft patients
Authors: Tarkka MR, Kaukinen S, Holm P, Kaukinen U, Sisto T, Kataja J, Huang WQ
Publisher: TAYLOR & FRANCIS AS
Publication year: 2000
Journal name in source: SCANDINAVIAN CARDIOVASCULAR JOURNAL
Journal acronym: SCAND CARDIOVASC J
Volume: 34
Issue: 4
First page : 409
Last page: 414
Number of pages: 6
ISSN: 1401-7431
Abstract
Objectives: Allopurinol protects the heart against ischaemic events during coronary artery bypass grafting (CABG), possibly because of its antioxidant properties. This double-blind study was designed to investigate whether allopurinol (1 g), given before cardiopulmonary bypass and prior to the opening of cross-clamping, has an antioxidant effect in CABG patients by measuring plasma total peroxyl radical scavenging capacity.Design: Twenty-seven patients with stabile angina were randomized into allopurinol (n = 14) or placebo (n = 13) groups.Results: During 10 min reperfusion, plasma hypoxanthine and xanthine concentrations increased only in the allopurinol group, whereas uric acid concentrations decreased. Total peroxyl radical scavenging capacity (TRAP) decreased from the initial value at all measuring points in both groups.Conclusions: The reducing effect of allopurinol on free radical generation cannot be seen in TRAP values, obviously because the uric acid concentration of plasma decreases markedly. The positive clinical effects of allopurinol in CABG patients may arise from its direct oxygen free radical scavenging function.
Objectives: Allopurinol protects the heart against ischaemic events during coronary artery bypass grafting (CABG), possibly because of its antioxidant properties. This double-blind study was designed to investigate whether allopurinol (1 g), given before cardiopulmonary bypass and prior to the opening of cross-clamping, has an antioxidant effect in CABG patients by measuring plasma total peroxyl radical scavenging capacity.Design: Twenty-seven patients with stabile angina were randomized into allopurinol (n = 14) or placebo (n = 13) groups.Results: During 10 min reperfusion, plasma hypoxanthine and xanthine concentrations increased only in the allopurinol group, whereas uric acid concentrations decreased. Total peroxyl radical scavenging capacity (TRAP) decreased from the initial value at all measuring points in both groups.Conclusions: The reducing effect of allopurinol on free radical generation cannot be seen in TRAP values, obviously because the uric acid concentration of plasma decreases markedly. The positive clinical effects of allopurinol in CABG patients may arise from its direct oxygen free radical scavenging function.
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