A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients
Tekijät: Ubaida-Mohien C, Lamberty B, Dickens AM, Mielke MM, Marcotte T, Sacktor N, Grant I, Letendre S, Franklin D, Cibrowski P, Tharakan R, McArthur JC, Fox H, Haughey NJ
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2017
Journal: AIDS
Tietokannassa oleva lehden nimi: AIDS
Lehden akronyymi: AIDS
Vuosikerta: 31
Numero: 10
Aloitussivu: 1365
Lopetussivu: 1378
Sivujen määrä: 14
ISSN: 0269-9370
DOI: https://doi.org/10.1097/QAD.0000000000001503
Tiivistelmä
Background: The prevalence of HIV-associated neurocognitive disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation, and cellular stress have been repeatedly associated with HAND, but the underlying systems that drive these changes have not been identified.Method: In this study, we used systems informatics to interrogate the cerebrospinal fluid proteomic content of longitudinal samples obtained from HIV-infected adults with stably unimpaired, stably impaired, worsening, or improving neurocognitive performance.Results and conclusion: The patterns of change in cerebrospinal fluid protein content implicated the induction of acute phase and complement systems as important regulators of neurocognitive status. Worsening neurocognitive performance was preceded by induction of acute phase and complement systems, whereas improving neurocognitive performance was preceded by a downregulation of these systems. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
Background: The prevalence of HIV-associated neurocognitive disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation, and cellular stress have been repeatedly associated with HAND, but the underlying systems that drive these changes have not been identified.Method: In this study, we used systems informatics to interrogate the cerebrospinal fluid proteomic content of longitudinal samples obtained from HIV-infected adults with stably unimpaired, stably impaired, worsening, or improving neurocognitive performance.Results and conclusion: The patterns of change in cerebrospinal fluid protein content implicated the induction of acute phase and complement systems as important regulators of neurocognitive status. Worsening neurocognitive performance was preceded by induction of acute phase and complement systems, whereas improving neurocognitive performance was preceded by a downregulation of these systems. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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