A1 Refereed original research article in a scientific journal
Sex specific expression of progesterone receptor in mouse lower urinary tract
Authors: Savolainen S, Santti R, Streng T, Gustafsson JA, Harkonen P, Makela S
Publisher: ELSEVIER SCI IRELAND LTD
Publication year: 2005
Journal:Molecular and Cellular Endocrinology
Journal name in sourceMOLECULAR AND CELLULAR ENDOCRINOLOGY
Journal acronym: MOL CELL ENDOCRINOL
Volume: 230
Issue: 1-2
First page : 17
Last page: 21
Number of pages: 5
ISSN: 0303-7207
DOI: https://doi.org/10.1016/j.mce.2004.11.008
Abstract
PR was found to be co-expressed with ERalpha in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERalpha. In male urethra, PR was co-expressed with ERbeta in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
PR was found to be co-expressed with ERalpha in cell nuclei of urothelium, lamina propria fibroblasts and smooth muscle cells in the female urethra. Only few PR positive cells were seen in female ERKO mice. Ovariectomy reduced and estrogen treatment restored the urethral PR expression in female wild type and BERKO mice. Thus, the expression of PR in the female urethra is estrogen-inducible via ERalpha. In male urethra, PR was co-expressed with ERbeta in the rhabdosphincter. In male, no evidence was obtained for the ER-linked control of the PR expression. No PR-positive cells were observed in the body of the bladder of either sex or any strain. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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