Epitope Specificity and IgG Subclass Distribution of Autoantibodies to Cardiac Troponin



: Savukoski T, Twarda A, Hellberg S, Ristiniemi N, Wittfooth S, Sinisalo J, Pettersson K

Publisher: AMER ASSOC CLINICAL CHEMISTRY

: 2013

: Clinical Chemistry

: CLINICAL CHEMISTRY

: CLIN CHEM

: 3

: 59

: 3

: 512

: 518

: 7

: 0009-9147

DOI: https://doi.org/10.1373/clinchem.2012.194860


CONCLUSIONS: IgG subclass studies confirm that cTnAAb formation may be triggered/boosted in acute cardiac events. This new information about the epitope specificity of cTnAAbs should be used to reevaluate existing recommendations regarding use of midfragment epitopes in cTnI assays. To circumvent the negative interference of the highly heterogeneous cTnAAbs, use of 3 or more unconventionally selected epitopes should be considered. (C) 2012 American Association for Clinical Chemistry



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