A1 Refereed original research article in a scientific journal
Microscale granulation in a fluid bed powder processor using electrostatic atomisation
Authors: Kivikero N, Murtomaa M, Ingelbeen B, Antikainen O, Rasanen E, Mannermaa JP, Juppo AM
Publisher: ELSEVIER SCIENCE BV
Publication year: 2009
Journal:: European Journal of Pharmaceutics and Biopharmaceutics
Journal name in source: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Journal acronym: EUR J PHARM BIOPHARM
Volume: 71
Issue: 1
First page : 130
Last page: 137
Number of pages: 8
ISSN: 0939-6411
DOI: https://doi.org/10.1016/j.ejpb.2008.07.009
Abstract
The aim of this study was to use the electrostatic atomisation in miniaturised fluid bed granulation process and define the effect of process parameters. The process parameters included in the study were granulation liquid flow rate, atomisation voltage and binder concentration in the granulation liquid. Altogether 22 batches were granulated in Multichamber Microscale Fluid bed powder Processor (MMFP). Granule size distributions were measured with both sieves and image analyses. With these process conditions, the atomisation liquid flow rate had a strong positive correlation with the granule size. Increasing the atomisation voltage increased the granule size, which is contradictory with the expectations. The effect of the binder concentration remained unclear. Although it is challenging to model the fluid bed granulation process in micro-scale, multivariate methods Such as principal component analysis (PCA) are helpful in studying the most important phenomena. (c) 2008 Elsevier B.V. All rights reserved.
The aim of this study was to use the electrostatic atomisation in miniaturised fluid bed granulation process and define the effect of process parameters. The process parameters included in the study were granulation liquid flow rate, atomisation voltage and binder concentration in the granulation liquid. Altogether 22 batches were granulated in Multichamber Microscale Fluid bed powder Processor (MMFP). Granule size distributions were measured with both sieves and image analyses. With these process conditions, the atomisation liquid flow rate had a strong positive correlation with the granule size. Increasing the atomisation voltage increased the granule size, which is contradictory with the expectations. The effect of the binder concentration remained unclear. Although it is challenging to model the fluid bed granulation process in micro-scale, multivariate methods Such as principal component analysis (PCA) are helpful in studying the most important phenomena. (c) 2008 Elsevier B.V. All rights reserved.
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