Refereed journal article or data article (A1)

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

List of AuthorsSantio NM, Eerola SK, Paatero I, Yli-Kauhaluoma J, Anizon F, Moreau P, Tuomela J, Harkonen P, Koskinen PJ


Publication year2015

JournalPLoS ONE

Journal name in sourcePLOS ONE

Journal acronymPLOS ONE

Volume number10

Issue number6

Number of pages20




Our results indicate that Pim overexpression enhances the invasive properties of prostate cancer cells in vivo. These effects can be reduced by the Pim-selective inhibitor DHPCC-9, which can reach tumor tissues without serious side effects. Thus, Pim-targeting therapies with DHPCC-9-like compounds may help to prevent progression of local prostate carcinomas to fatally metastatic malignancies.

Last updated on 2021-24-06 at 08:20