Refereed journal article or data article (A1)

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts



List of Authors: Santio NM, Eerola SK, Paatero I, Yli-Kauhaluoma J, Anizon F, Moreau P, Tuomela J, Harkonen P, Koskinen PJ

Publisher: PUBLIC LIBRARY SCIENCE

Publication year: 2015

Journal: PLoS ONE

Journal name in source: PLOS ONE

Journal acronym: PLOS ONE

Volume number: 10

Issue number: 6

Number of pages: 20

ISSN: 1932-6203

DOI: http://dx.doi.org/10.1371/journal.pone.0130340


Abstract

Our results indicate that Pim overexpression enhances the invasive properties of prostate cancer cells in vivo. These effects can be reduced by the Pim-selective inhibitor DHPCC-9, which can reach tumor tissues without serious side effects. Thus, Pim-targeting therapies with DHPCC-9-like compounds may help to prevent progression of local prostate carcinomas to fatally metastatic malignancies.



Last updated on 2021-24-06 at 08:20