Sequential Cohort Design Applying Propensity Score Matching to Analyze the Comparative Effectiveness of Atorvastatin and Simvastatin in Preventing Cardiovascular Events

: Helin-Salmivaara A, Lavikainen P, Aarnio E, Huupponen R, Korhonen MJ

Publisher: PUBLIC LIBRARY SCIENCE

: 2014

: PLoS ONE

: PLOS ONE

: ARTN e90325

: 9

: 3

: 9

: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0090325

Conclusions: The SCD PS approach produced effect estimates similar to those obtained in matching for PS within the whole cohort and adjusting the outcome model for strong confounders, but at the cost of efficiency. A traditional PS matched analysis without further adjustment in the outcome model produced estimates further away from unity.