A1 Refereed original research article in a scientific journal
Directed Overlap-inclusion Graphs as Representations of Ciliate Genes
Authors: Azimi S, Harju T, Langille M, Petre I, Rogojin V
Publisher: IOS PRESS
Publication year: 2011
Journal: Fundamenta Informaticae
Journal name in source: FUNDAMENTA INFORMATICAE
Journal acronym: FUND INFORM
Number in series: 1-4
Volume: 110
Issue: 1-4
First page : 29
Last page: 44
Number of pages: 16
ISSN: 0169-2968
DOI: https://doi.org/10.3233/FI-2011-526
Abstract
The simple intramolecular model for gene assembly in ciliates consists of three molecular operations based on local DNA manipulations. It was shown to predict correctly the assembly of all currently known ciliate gene patterns. Mathematical models in terms of signed permutations and signed strings proved limited in capturing some of the combinatorial details of the simple gene assembly process. A different formalization in terms of overlap-inclusion graphs, recently introduced by Brijder and Hoogeboom, proved well-suited to describe two of the three operations of the model and their combinatorial properties. We introduce in this paper an extension of the framework of Brijder and Hoogeboom in terms of directed overlap-inclusion graphs where more of the linear structure of the ciliate genes is described. We investigate a number of combinatorial properties of these graphs, including a necessary property in terms of forbidden induced subgraphs.
The simple intramolecular model for gene assembly in ciliates consists of three molecular operations based on local DNA manipulations. It was shown to predict correctly the assembly of all currently known ciliate gene patterns. Mathematical models in terms of signed permutations and signed strings proved limited in capturing some of the combinatorial details of the simple gene assembly process. A different formalization in terms of overlap-inclusion graphs, recently introduced by Brijder and Hoogeboom, proved well-suited to describe two of the three operations of the model and their combinatorial properties. We introduce in this paper an extension of the framework of Brijder and Hoogeboom in terms of directed overlap-inclusion graphs where more of the linear structure of the ciliate genes is described. We investigate a number of combinatorial properties of these graphs, including a necessary property in terms of forbidden induced subgraphs.
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