A1 Refereed original research article in a scientific journal
Early Vascular Healing After Endothelial Progenitor Cell Capturing Stent Implantation
Authors: Lehtinen T, Kiviniemi TO, Ylitalo A, Mikkelsson J, Airaksinen JKE, Karjalainen PP
Publisher: H M P COMMUNICATIONS
Publication year: 2012
Journal: Journal of Invasive Cardiology
Journal name in source: JOURNAL OF INVASIVE CARDIOLOGY
Journal acronym: J INVASIVE CARDIOL
Number in series: 12
Volume: 24
Issue: 12
First page : 631
Last page: 635
Number of pages: 5
ISSN: 1042-3931
Abstract
Objectives. To assess early vascular healing with endothelial progenitor cell (EPC)-capturing stents. Background. Endothelialization of stent struts is crucial after stenting, since delayed vascular healing predisposes to stent thrombosis. The antibody-coated Genous stent promotes rapid endothelialization by capturing circulating EPCs. Methods. We enrolled 20 patients who had EPC-capturing stent implanted in the left anterior descending (LAD) coronary artery. Patients underwent optical coherence tomography 30 days following the index procedure. Coronary flow reserve (CFR) was assessed in the LAD by transthoracic echocardiography at 30 days. Results. After follow-up of 31.8 +/- 5.3 days, the binary stent strut coverage was 95% and the percentage of malapposed struts was 2.4%. No thrombi were detected. The mean neointimal hyperplasia (NIH) thickness was 108 +/- 96 mu m and the percent NIH area was 8.9 +/- 7.4%. The mean CFR was 2.4 +/- 0.7. Conclusions. The EPC-capturing stent showed rapid endothelialization, low NIH area, and few malapposed struts at 30 days. J INVASIVE CARDIOL 2012;24(12):631-635
Objectives. To assess early vascular healing with endothelial progenitor cell (EPC)-capturing stents. Background. Endothelialization of stent struts is crucial after stenting, since delayed vascular healing predisposes to stent thrombosis. The antibody-coated Genous stent promotes rapid endothelialization by capturing circulating EPCs. Methods. We enrolled 20 patients who had EPC-capturing stent implanted in the left anterior descending (LAD) coronary artery. Patients underwent optical coherence tomography 30 days following the index procedure. Coronary flow reserve (CFR) was assessed in the LAD by transthoracic echocardiography at 30 days. Results. After follow-up of 31.8 +/- 5.3 days, the binary stent strut coverage was 95% and the percentage of malapposed struts was 2.4%. No thrombi were detected. The mean neointimal hyperplasia (NIH) thickness was 108 +/- 96 mu m and the percent NIH area was 8.9 +/- 7.4%. The mean CFR was 2.4 +/- 0.7. Conclusions. The EPC-capturing stent showed rapid endothelialization, low NIH area, and few malapposed struts at 30 days. J INVASIVE CARDIOL 2012;24(12):631-635
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