A1 Refereed original research article in a scientific journal
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
Authors: Okada, Sim, Go, Wu, Gu, Takeuchi, Takahashi, Maeda, Tsunoda, Chen, Lim, Wong, Liu, Young, Aung, Seielstad, Teo, Kim, Lee, Han, Kang, Chen, Tsai, Chang, Fann, Mei, Rao, Hixson, Chen, Katsuya, Isono, Ogihara, Chambers, Zhang, Kooner, KidneyGen Consortium, CKDGen Consortium, Albrecht, GUGC consortium, Yamamoto, Kubo, Nakamura, Kamatani, Kato, He, Chen, Cho, Tai, Tanaka
Publication year: 2012
Journal: Nature Genetics
Journal name in source: Nature genetics
Journal acronym: Nat Genet
Number in series: 8
Volume: 44
Issue: 8
First page : 904
Last page: 909
Number of pages: 7
ISSN: 1061-4036
DOI: https://doi.org/10.1038/ng.2352
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
