A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
The transition to modernity and chronic disease: mismatch and natural selection
Tekijät: Stephen Corbett, Alexandre Courtiol, Virpi Lummaa, Jacob Moorad, Stephen Stearns
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2018
Journal: Nature Reviews Genetics
Tietokannassa oleva lehden nimi: NATURE REVIEWS GENETICS
Lehden akronyymi: NAT REV GENET
Vuosikerta: 19
Numero: 7
Aloitussivu: 419
Lopetussivu: 430
Sivujen määrä: 12
ISSN: 1471-0056
eISSN: 1471-0064
DOI: https://doi.org/10.1038/s41576-018-0012-3
Tiivistelmä
The Industrial Revolution and the accompanying nutritional, epidemiological and demographic transitions have profoundly changed human ecology and biology, leading to major shifts in life history traits, which include age and size at maturity, age-specific fertility and lifespan. Mismatch between past adaptations and the current environment means that gene variants linked to higher fitness in the past may now, through antagonistic pleiotropic effects, predispose post-transition populations to non-communicable diseases, such as Alzheimer disease, cancer and coronary artery disease. Increasing evidence suggests that the transition to modernity has also altered the direction and intensity of natural selection acting on many traits, with important implications for public and global health.
The Industrial Revolution and the accompanying nutritional, epidemiological and demographic transitions have profoundly changed human ecology and biology, leading to major shifts in life history traits, which include age and size at maturity, age-specific fertility and lifespan. Mismatch between past adaptations and the current environment means that gene variants linked to higher fitness in the past may now, through antagonistic pleiotropic effects, predispose post-transition populations to non-communicable diseases, such as Alzheimer disease, cancer and coronary artery disease. Increasing evidence suggests that the transition to modernity has also altered the direction and intensity of natural selection acting on many traits, with important implications for public and global health.
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