A1 Journal article – refereed

5 ',5 '-Phosphodiesters and esterase labile triesters of 2 '-C-methylribonucleosides

List of Authors: Leisvuori A, Ahmed Z, Ora M, Blatt L, Beigelman L, Lonnberg H

Publisher: ARKAT USA INC

Publication year: 2012

Journal: Arkivoc

Journal name in source: ARKIVOC

Journal acronym: ARKIVOC

Issue number: 5

Number of pages: 18

ISSN: 1551-7004

DOI: http://dx.doi.org/10.3998/ark.5550190.0013.520

Bis(2'-C-methyladenosin-5'-yl) (11), bis(2'-C-methylguanosin-5'-yl) (13), bis(2'-C-methyluridin-5'-yl) (15) and 2'-C-methylguanosin-5'-yl 2'-C-methyluridin-5'-yl (16) phosphodiesters have been prepared as pro-drug candidates for the respective 2'-C-methylribonucleoside 5'-monophosphates, expectedly exhibiting antiviral activity against Hepatitis C virus. Additionally, the bis(2'-C-methyladenosine) diester has been converted to 3-acetyloxymethoxy-2,2-bis(ethoxycarbonyl)propyl (19) or pivaloyloxymethyl (20) triester. The underlying idea is that the 5',5'-phosphodiester is first released by intracellular carboxyesterases and subsequently cleaved to nucleoside and nucleoside 5'-monophosphate by phosphodiesterases.

Research Areas

Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Last updated on 2021-24-06 at 08:17