A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Twinning propensity and offspring in utero growth covary in rural African women
Tekijät: Rickard IJ, Prentice AM, Fulford AJC, Lummaa V
Kustantaja: ROYAL SOC
Julkaisuvuosi: 2012
Journal: Biology Letters
Tietokannassa oleva lehden nimi: BIOLOGY LETTERS
Lehden akronyymi: BIOL LETTERS
Vuosikerta: 8
Numero: 1
Aloitussivu: 67
Lopetussivu: 70
Sivujen määrä: 4
ISSN: 1744-9561
DOI: https://doi.org/10.1098/rsbl.2011.0598
Tiivistelmä
In humans and other mammals, some females are more likely to experience twin pregnancies than others, but the reasons behind such individual variation are poorly understood. One hypothesis invokes variation in the dynamics of the insulin-like growth factor (IGF) system, which also regulates foetal growth. Using data from a rural African population living in a highly seasonal environment, we test a novel prediction generated by this hypothesis, that maternal twinning status predicts offspring birthweight. We found that among singleton offspring who experience a favourable in utero environment (born January-June), births before and after twins are, respectively, associated with a 134.07 g and 226.41 g increase in birthweight compared with those born to non-twinning mothers. These results were not mediated by maternal anthropometry. This is consistent with a role for the IGF system in individual variation in twinning propensity, a possibility with implications for understanding mechanisms of life-history variation in humans and other vertebrates.
In humans and other mammals, some females are more likely to experience twin pregnancies than others, but the reasons behind such individual variation are poorly understood. One hypothesis invokes variation in the dynamics of the insulin-like growth factor (IGF) system, which also regulates foetal growth. Using data from a rural African population living in a highly seasonal environment, we test a novel prediction generated by this hypothesis, that maternal twinning status predicts offspring birthweight. We found that among singleton offspring who experience a favourable in utero environment (born January-June), births before and after twins are, respectively, associated with a 134.07 g and 226.41 g increase in birthweight compared with those born to non-twinning mothers. These results were not mediated by maternal anthropometry. This is consistent with a role for the IGF system in individual variation in twinning propensity, a possibility with implications for understanding mechanisms of life-history variation in humans and other vertebrates.
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