Recent clinical evidence indicates potential of berry-rich diet in controlling the risk of chronic diseases. Acute consumption of berries ameliorates postprandial glycemic response, improves profile of circulating inflammatory markers and increases antioxidative capacity of plasma. Long-term intake of berries and berry products may improve plasma lipid profile, reduce chronic inflammation and support cardiovascular health, especially in population with baseline metabolic profile of increased risk for metabolic syndrome. Dietary intervention with berry seed oils in early stage of life may reduce prevalence of atopic diseases. More research shall be directed to investigate the potential of berries and berry products in combating stress, promoting healthy aging and improving gut health.