A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis
Tekijät: Yilmaz D, Caglayan F, Buber E, Kononen E, Aksoy Y, Gursoy UK, Guncu GN
Kustantaja: SPRINGER HEIDELBERG
Kustannuspaikka: Heidelberg
Julkaisuvuosi: 2018
Journal: Clinical Oral Investigations
Tietokannassa oleva lehden nimi: CLINICAL ORAL INVESTIGATIONS
Lehden akronyymi: CLIN ORAL INVEST
Vuosikerta: 22
Numero: 5
Aloitussivu: 2135
Lopetussivu: 2140
Sivujen määrä: 6
ISSN: 1432-6981
eISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-018-2469-z
Tiivistelmä
Objectives Human beta-defensin (hBD)-1 is an important gatekeeper of the gingiva against constant bacterial challenge, and glucose levels are involved in its optimal expression. The aims of the study were to investigate hBD-1 levels in gingival crevicular fluid (GCF) and to compare these levels between type 2 diabetics with or without periodontitis and healthy individuals.Materials and Methods Altogether, 81 subjects were included in the study: 21 subjects with type 2 diabetes mellitus (T2DM) suffering from generalized periodontitis (T2DM + GP), 18 systemically healthy generalized periodontitis patients (GP), 18 periodontally healthy T2DM subjects (T2DM + H), and 24 systemically and periodontally healthy subjects (control). Plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded, and GCF samples were collected. hBD-1 levels in GCF were measured using ELISA.Results hBD-1 levels were significantly reduced in the T2DM + GP and GP groups. Although PI and GI scores were similar in both periodontally healthy groups, hBD-1 levels were lower in the T2DM + H group. In the whole population, hBD-1 levels correlated negatively with all periodontal parameters.Conclusions Both diabetes and periodontitis affect hBD-1 levels in GCF.
Objectives Human beta-defensin (hBD)-1 is an important gatekeeper of the gingiva against constant bacterial challenge, and glucose levels are involved in its optimal expression. The aims of the study were to investigate hBD-1 levels in gingival crevicular fluid (GCF) and to compare these levels between type 2 diabetics with or without periodontitis and healthy individuals.Materials and Methods Altogether, 81 subjects were included in the study: 21 subjects with type 2 diabetes mellitus (T2DM) suffering from generalized periodontitis (T2DM + GP), 18 systemically healthy generalized periodontitis patients (GP), 18 periodontally healthy T2DM subjects (T2DM + H), and 24 systemically and periodontally healthy subjects (control). Plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded, and GCF samples were collected. hBD-1 levels in GCF were measured using ELISA.Results hBD-1 levels were significantly reduced in the T2DM + GP and GP groups. Although PI and GI scores were similar in both periodontally healthy groups, hBD-1 levels were lower in the T2DM + H group. In the whole population, hBD-1 levels correlated negatively with all periodontal parameters.Conclusions Both diabetes and periodontitis affect hBD-1 levels in GCF.
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