D2 Artikkeli ammatillisessa kokoomateoksessa
Lymphocytes: Recirculation
Tekijät: Sirpa Jalkanen, Marko Salmi
Toimittaja: Peter Delves
Kustantaja: John Wiley and Sons
Julkaisuvuosi: 2013
Kokoomateoksen nimi: eLS
DOI: https://doi.org/10.1002/9780470015902.a0001200.pub3
Tiivistelmä
Successful immunosurveillance requires endless patrolling of lymphoid tissues by lymphocytes in search of foreign antigens. Lymphocytes enter the lymphoid tissues either through the blood vessel walls or via the afferent lymphatic vessels. To leave the circulation, bloodborne lymphocytes first tether to the endothelial lining of the vessels and start to roll. After an activation step they firmly adhere and transmigrate through the vessel wall. They then navigate through the tissue stroma following chemotactic and other guidance molecules, possibly encounter their cognate antigens and eventually return via the lymphatic vessels back into the blood to be dispersed to the other tissues of the body. In this tightly controlled process called lymphocyte recirculation, different adhesion molecules and activation signals on the two opposing cell types play a critical role. Dysregulated lymphocyte recirculation is involved in the pathogenesis of many inflammatory diseases and immunodeficiencies, and nowadays several drugs target this process.
Successful immunosurveillance requires endless patrolling of lymphoid tissues by lymphocytes in search of foreign antigens. Lymphocytes enter the lymphoid tissues either through the blood vessel walls or via the afferent lymphatic vessels. To leave the circulation, bloodborne lymphocytes first tether to the endothelial lining of the vessels and start to roll. After an activation step they firmly adhere and transmigrate through the vessel wall. They then navigate through the tissue stroma following chemotactic and other guidance molecules, possibly encounter their cognate antigens and eventually return via the lymphatic vessels back into the blood to be dispersed to the other tissues of the body. In this tightly controlled process called lymphocyte recirculation, different adhesion molecules and activation signals on the two opposing cell types play a critical role. Dysregulated lymphocyte recirculation is involved in the pathogenesis of many inflammatory diseases and immunodeficiencies, and nowadays several drugs target this process.
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