Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2)
Adhesive organelles of Gram-negative pathogens assembled with the classical chaperone/usher machinery: structure and function from a clinical standpoint
Julkaisun tekijät: Zav'yalov V, Zavialov A, Zav'yalova G, Korpela T
Kustantaja: WILEY-BLACKWELL PUBLISHING, INC
Julkaisuvuosi: 2010
Journal: FEMS Microbiology Reviews
Tietokannassa oleva lehden nimi: FEMS MICROBIOLOGY REVIEWS
Lehden akronyymi: FEMS MICROBIOL REV
Numero sarjassa: 3
Volyymi: 34
Julkaisunumero: 3
Aloitussivu: 317
Lopetussivun numero: 378
Sivujen määrä: 62
ISSN: 0168-6445
DOI: http://dx.doi.org/10.1111/j.1574-6976.2009.00201.x
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/Publication/3120686
This review summarizes current knowledge on the structure, function, assembly and biomedical applications of the superfamily of adhesive fimbrial organelles exposed on the surface of Gram-negative pathogens with the classical chaperone/usher machinery. High-resolution three-dimensional (3D) structure studies of the minifibers assembling with the FGL (having a long F1-G1 loop) and FGS (having a short F1-G1 loop) chaperones show that they exploit the same principle of donor-strand complementation for polymerization of subunits. The 3D structure of adhesive subunits bound to host-cell receptors and the final architecture of adhesive fimbrial organelles reveal two functional families of the organelles, respectively, possessing polyadhesive and monoadhesive binding. The FGL and FGS chaperone-assembled polyadhesins are encoded exclusively by the gene clusters of the gamma 3- and kappa-monophyletic groups, respectively, while gene clusters belonging to the gamma 1-, gamma 2-, gamma 4-, and pi-fimbrial clades exclusively encode FGS chaperone-assembled monoadhesins. Novel approaches are suggested for a rational design of antimicrobials inhibiting the organelle assembly or inhibiting their binding to host-cell receptors. Vaccines are currently under development based on the recombinant subunits of adhesins.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
