Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Genetically modified mouse models to investigate thyroid development, function and growth




Julkaisun tekijät: C. Löf, K. Patyra, A. Kero, J. Kero

Kustantaja: Bailliere Tindall Ltd

Julkaisuvuosi: 2018

Journal: Best Practice and Research: Clinical Endocrinology and Metabolism

Tietokannassa oleva lehden nimi: Best Practice and Research: Clinical Endocrinology and Metabolism

Volyymi: 32

Julkaisunumero: 3

Sivujen määrä: 16

ISSN: 1521-690X

eISSN: 1878-1594

DOI: http://dx.doi.org/10.1016/j.beem.2018.03.007


Tiivistelmä

The thyroid gland produces thyroid hormones (TH), which are essential regulators for growth, development and metabolism. The thyroid is mainly controlled by the thyroid-stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its action via different G protein-mediated signaling pathways. TSH primarily activates the Gs-pathway, and at higher concentrations also the Gq/11-pathway, leading to an increase of intracellular cAMP and Ca2+, respectively. To date, the physiological importance of other G protein-mediated signaling pathways in thyrocytes is unclear. Congenital hypothyroidism (CH) is defined as the lack of TH at birth. In familial cases, high-throughput sequencing methods have facilitated the identification of novel mutations. Nevertheless, the precise etiology of CH yet remains unraveled in a proportion of cases. Genetically modified mouse models can reveal new pathophysiological mechanisms of thyroid diseases. Here, we will present an overview of genetic mouse models for thyroid diseases, which have provided crucial insights into thyroid gland development, function, and growth with a special focus on TSHR and microRNA signaling.


Last updated on 2021-24-06 at 10:50