A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Circulating oxidized LDL lipids, when proportioned to HDL-c, emerged as a risk factor of all-cause mortality in a population-based survival study
Tekijät: Linna M, Ahotupa M, Löppönen MK, Irjala K, Vasankari T
Julkaisuvuosi: 2013
Journal: Age and Ageing
Numero sarjassa: 1
Vuosikerta: 42
Numero: 1
Aloitussivu: 110
Lopetussivu: 113
Sivujen määrä: 4
ISSN: 0002-0729
DOI: https://doi.org/10.1093/ageing/afs074
Background and objective: the data concerning the predictive role of oxidised LDL (ox-LDL) in all-cause mortality are scarce. We investigated whether circulating ox-LDL would stand out as a risk factor of total mortality in the elderly. Study subjects, design and methods: a total of 1,260 elderly inhabitants (533 men, 727 women) aged 64 years or more from Lieto, South-Western Finland participated the study in 1998-99. Medical records were re-examined approximately a decade later in January 2009. Circulating ox-LDL lipids were used as the main outcome measure. The comparisons were obtained by the Cox hazard ratio model.
RESULTS:
during the 10-year follow-up, 467 participants had died (37%), of whom 36% had died of atherosclerotic cardiovascular diseases. Ox-LDL was a significant predictor of all-cause mortality, when proportioned to low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) or apolipoprotein A1 (apoA1). These findings were independent of age, sex, body mass index, smoking, blood pressure and diabetes (P < 0.05 for all).
CONCLUSION:
circulating ox-LDL lipids, when proportioned to LDL-c, HDL-c or apoaA1, stand out as a risk factor for all-cause mortality independent of major confounding attributes. In the prospective survival and increasing disease burden caused by accumulating age, oxidative stress may have a considerable role.
