A1 Refereed original research article in a scientific journal
Impulse oscillometry at preschool age is a strong predictor of lung function by flow-volume spirometry in adolescence
Authors: Lauhkonen E, Riikonen R, Tormanen S, Koponen P, Nuolivirta K, Helminen M, Toikka J, Korppi M
Publisher: WILEY
Publication year: 2018
Journal: Pediatric Pulmonology
Journal name in source: PEDIATRIC PULMONOLOGY
Journal acronym: PEDIATR PULM
Volume: 53
Issue: 5
First page : 552
Last page: 558
Number of pages: 7
ISSN: 8755-6863
DOI: https://doi.org/10.1002/ppul.23977
Abstract
BackgroundThe transition from early childhood wheezing to persistent asthma is linked to lung function impairment over time. Little is known how the methods used to study lung function at different ages correlate longitudinally.MethodsSixty-four children with a history of hospitalization for bronchiolitis before 6 months of age were prospectively studied with impulse oscillometry (IOS) at the mean age of 6.3 years and these preschool IOS results were compared with flow-volume spirometry (FVS) measurements at mean age of 11.4 years.ResultsThe baseline respiratory system resistance at 5Hz (Rrs5) showed a modest statistically significant correlation with all baseline FVS parameters except FVC. The post-bronchodilator (post-BD) Rrs5 showed a modest statistically significant correlation with post-BD FEV1 and FEV1/FVC. The bronchodilator-induced decrease in Rrs5 showed a modest statistically significant correlation with the percent increase in FEV1. Baseline and post-BD respiratory reactance at 5Hz (Xrs5) showed a modest statistically significant correlation with baseline and post-BD FVS parameters except post-BD FEV1/FVC, respectively, and post-BD Xrs5 showed a strong correlation with post-BD FVC (=0.61) and post-BD FEV1 (=0.59). In adjusted linear regression, preschool Xrs5 remained as a statistically significant independent predictor of FVS parameters in adolescence; the one-unit decrease in the Z-score of preschool post-BD Xrs5 predicted 9.6% lower post-BD FEV1, 9.3% lower post-BD FVC, and 9.7% lower post-BD MEF50 when expressed as %-predicted parameters.ConclusionPersistent post-BD small airway impairment in children with a history of bronchiolitis detected with IOS at preschool age predicted FVS results measured in early adolescence.
BackgroundThe transition from early childhood wheezing to persistent asthma is linked to lung function impairment over time. Little is known how the methods used to study lung function at different ages correlate longitudinally.MethodsSixty-four children with a history of hospitalization for bronchiolitis before 6 months of age were prospectively studied with impulse oscillometry (IOS) at the mean age of 6.3 years and these preschool IOS results were compared with flow-volume spirometry (FVS) measurements at mean age of 11.4 years.ResultsThe baseline respiratory system resistance at 5Hz (Rrs5) showed a modest statistically significant correlation with all baseline FVS parameters except FVC. The post-bronchodilator (post-BD) Rrs5 showed a modest statistically significant correlation with post-BD FEV1 and FEV1/FVC. The bronchodilator-induced decrease in Rrs5 showed a modest statistically significant correlation with the percent increase in FEV1. Baseline and post-BD respiratory reactance at 5Hz (Xrs5) showed a modest statistically significant correlation with baseline and post-BD FVS parameters except post-BD FEV1/FVC, respectively, and post-BD Xrs5 showed a strong correlation with post-BD FVC (=0.61) and post-BD FEV1 (=0.59). In adjusted linear regression, preschool Xrs5 remained as a statistically significant independent predictor of FVS parameters in adolescence; the one-unit decrease in the Z-score of preschool post-BD Xrs5 predicted 9.6% lower post-BD FEV1, 9.3% lower post-BD FVC, and 9.7% lower post-BD MEF50 when expressed as %-predicted parameters.ConclusionPersistent post-BD small airway impairment in children with a history of bronchiolitis detected with IOS at preschool age predicted FVS results measured in early adolescence.
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