A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer - UTU Research Portal

A1 Refereed original research article in a scientific journal

A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer

Authors: Stegeman S, Amankwah E, Klein K, O'Mara TA, Kim D, Lin HY, Permuth-Wey J, Sellers TA, Srinivasan S, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pharoah P, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Kaneva R, Teixeira MR, Spurdle AB, Clements JA, Park JY, Batra J

Publisher: AMER ASSOC CANCER RESEARCH

Publication year: 2015

Journal: Cancer Discovery

Journal name in source: CANCER DISCOVERY

Journal acronym: CANCER DISCOV

Volume: 5

Issue: 4

First page : 368

Last page: 379

Number of pages: 12

ISSN: 2159-8274

eISSN: 2159-8290

DOI: https://doi.org/10.1158/2159-8290.CD-14-1057

Abstract

SIGNIFICANCE: Findings from this large association study suggest that a focus on miRSNPs, including functional evaluation, can identify candidate risk loci below currently accepted statistical levels of genome-wide significance. Studies of miRNAs and their interactions with SNPs could provide further insights into the mechanisms of prostate cancer risk. (C)2015 AACR.