Quantification of Myocardial Blood Flow in Absolute Terms Using (82)Rb PET Imaging: the RUBY-10 Study - UTU Tutkimustietojärjestelmä

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Quantification of Myocardial Blood Flow in Absolute Terms Using (82)Rb PET Imaging: the RUBY-10 Study

Tekijät: Nesterov SV, Deshayes E, Sciagrà R, Settimo L, Declerck JM, Pan XB, Yoshinaga K, Katoh C, Slomka PJ, Germano G, Han C, Aalto V, Alessio AM, Ficaro EP, Lee BC, Nekolla SG, Gwet KL, deKemp RA, Klein R, Dickson J, Case JA, Bateman T, Prior JO, Knuuti JM.

Julkaisuvuosi: 2014

Journal: JACC: Cardiovascular Imaging

Lehden akronyymi: JACC Cardiovasc Imaging

Vuosikerta: 7

Numero: 11

Aloitussivu: 1119

Lopetussivu: 1127

Sivujen määrä: 9

ISSN: 1936-878X

DOI: https://doi.org/10.1016/j.jcmg.2014.08.003

Tiivistelmä

Objectives

The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography (⁸²Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models.

Background

It is unknown how MBF and MFR values from existing SPs agree for 82Rb PET.

Methods

Rest and stress ⁸²Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs.

Results

The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM.

Conclusions

SPs using the most common kinetic model—OHI-1-TCM—provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.