A1 Refereed original research article in a scientific journal
Education-corrected CERAD identifies MCI and dementia in Parkinson's disease
Authors: Karrasch M, Laatu S, Ellfolk U, Marttila R, Martikainen K
Publisher: WILEY-BLACKWELL
Publication year: 2015
Journal: Acta Neurologica Scandinavica
Journal name in source: ACTA NEUROLOGICA SCANDINAVICA
Journal acronym: ACTA NEUROL SCAND
Volume: 131
Issue: 4
First page : 219
Last page: 224
Number of pages: 6
ISSN: 0001-6314
DOI: https://doi.org/10.1111/ane.12310
Objectives - This study examined whether controlling for educational background in the CERAD cognitive screening battery would affect the likelihood of patients with Parkinson's disease to fulfill criteria for mild cognitive impairment (PD-MCI) and dementia (PDD). Materials & Methods - One-hundred seventeen patients with PD were studied. Cognitive impairment was determined as two subtest scores falling below either the standard cutoff scores or education-corrected cutoff scores. The presence of dementia was determined by clinical interview or Clinical Dementia Rating. Patients were then classified as PD-MCI and PDD according to cognitive test performance and presence/absence of dementia. Results - The number of cognitively impaired patients (PD-MCI or PDD) was significantly higher when education-controlled cutoff scores were used (62.5% vs 38%). Correspondingly, the number of false negatives (demented PD patients performing normally in CERAD) was significantly lower when education-corrected cutoff scores were used (4% vs 10%). Conclusions Controlling for education increases the sensitivity of the CERAD for PD-MCI and PDD.