A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response
Tekijät: Schwarz E, Maukonen J, Hyytiainen T, Kieseppa T, Oresic M, Sabunciyan S, Mantere O, Saarela M, Yolken R, Suvisaari J
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2018
Journal: Schizophrenia Research
Tietokannassa oleva lehden nimi: SCHIZOPHRENIA RESEARCH
Lehden akronyymi: SCHIZOPHR RES
Vuosikerta: 192
Aloitussivu: 398
Lopetussivu: 403
Sivujen määrä: 6
ISSN: 0920-9964
eISSN: 1573-2509
DOI: https://doi.org/10.1016/j.schres.2017.04.017
Tiivistelmä
The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission. (C) 2017 Elsevier B.V. All rights reserved.
The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12 months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12 months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission. (C) 2017 Elsevier B.V. All rights reserved.
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