A1 Refereed original research article in a scientific journal
Value of DAPT score to predict adverse outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention: A post-hoc analysis from the AFCAS registry
Authors: Nammas W, Kiviniemi T, Schlitt A, Rubboli A, Valencia J, Lip GYH, Karjalainen PP, Biancari F, Airaksinen KEJ
Publisher: ELSEVIER IRELAND LTD
Publication year: 2018
Journal: International Journal of Cardiology
Journal name in source: INTERNATIONAL JOURNAL OF CARDIOLOGY
Journal acronym: INT J CARDIOL
Volume: 253
First page : 35
Last page: 39
Number of pages: 5
ISSN: 0167-5273
eISSN: 1874-1754
DOI: https://doi.org/10.1016/j.ijcard.2017.07.074
Abstract
Background: The DAPT score identifies patients with expected benefit from extended dual antiplatelet therapy beyond 1 year after percutaneous coronary intervention (PCI). In a post-hoc analysis from the AFCAS registry, we explored the value of DAPT score to predict outcome in patients with atrial fibrillation (AF) undergoing PCI.Methods and results: Outcome measures included major adverse cardiac/cerebrovascular events (MACCE) [all-cause death, myocardial infarction, repeat revascularization, stent thrombosis, or stroke/transient ischemic attack] and bleeding events. At 12-month follow-up, patients with a DAPT score >= 1 had a higher incidence of MACCE, all-cause death, myocardial infarction (p = 0.004, p = 0.006, and p = 0.013, respectively), but a similar bleeding rate (p = 0.66), versus those with a DAPT score <1. In a subgroup of patients at high risk of stroke who received triple therapy for 1 month only, DAPT score >= 1 was associated with a higher incidence of MACCE, all-cause death, myocardial infarction (p = 0.002, p = 0.015, and p = 0.039, respectively), but a similar bleeding rate (p = 0.81).Conclusions: In AF patients undergoing PCI, a DAPT score >= 1 was associated with a higher incidence of thrombotic events, and a similar incidence of bleeding events, compared with a DAPT score <1. These results were consistent in patients at high risk of stroke who received triple therapy for 1 month. (c) 2017 Elsevier B.V. All rights reserved.
Background: The DAPT score identifies patients with expected benefit from extended dual antiplatelet therapy beyond 1 year after percutaneous coronary intervention (PCI). In a post-hoc analysis from the AFCAS registry, we explored the value of DAPT score to predict outcome in patients with atrial fibrillation (AF) undergoing PCI.Methods and results: Outcome measures included major adverse cardiac/cerebrovascular events (MACCE) [all-cause death, myocardial infarction, repeat revascularization, stent thrombosis, or stroke/transient ischemic attack] and bleeding events. At 12-month follow-up, patients with a DAPT score >= 1 had a higher incidence of MACCE, all-cause death, myocardial infarction (p = 0.004, p = 0.006, and p = 0.013, respectively), but a similar bleeding rate (p = 0.66), versus those with a DAPT score <1. In a subgroup of patients at high risk of stroke who received triple therapy for 1 month only, DAPT score >= 1 was associated with a higher incidence of MACCE, all-cause death, myocardial infarction (p = 0.002, p = 0.015, and p = 0.039, respectively), but a similar bleeding rate (p = 0.81).Conclusions: In AF patients undergoing PCI, a DAPT score >= 1 was associated with a higher incidence of thrombotic events, and a similar incidence of bleeding events, compared with a DAPT score <1. These results were consistent in patients at high risk of stroke who received triple therapy for 1 month. (c) 2017 Elsevier B.V. All rights reserved.
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