A1 Refereed original research article in a scientific journal
Quantitative characterization of porous commercial and experimental bone graft substitutes with microcomputed tomography.
Authors: Ylä-Soininmäki A, Moritz N, Turco G, Paoletti S, Aro HT
Publisher: Wiley Periodicals, Inc
Publication year: 2013
Journal: Journal of Biomedical Materials Research Part B: Applied Biomaterials
Journal acronym: J Biomed Mater Res Part B: Appl Biomater
Number in series: 8
Volume: 101B
Issue: 8
First page : 1538
Last page: 1548
Number of pages: 11
ISSN: 1552-4973
DOI: https://doi.org/10.1002/jbm.b.32975
Abstract
A large number of resorbable bone graft substitutes are being marketed as porous, but the total porosity being referred does not take into account many of the biologically important physical aspects of porosity. Therefore, to allow the direct comparison of different commercial products, there is a need to adopt guidelines for a standardized characterization. The aim of the study was to assess a microcomputed tomography-based method for the characterization of porous biomaterials to allow head-to-head comparison of these materials. The study included two commercial biomaterials (Actifuse® and ChronOs® ) and three experimental biomaterials (sintered bioactive glass microspheres, porous alginate (Alg), and porous Alg/hydroxyapatite composite). In addition to porosity and pore size distributions, the interconnectivity of the pores was assessed by an iterative blocking of interconnections. The biomaterials were characterized in their original morphologies (granules or cones). Differences between the materials were demonstrated. Actifuse® had the broadest distributions of pores and interconnections. ChronOs® had a substantial fraction of closed pores (10%). Other materials had closed porosity below 1%. Due to the thinner walls of the lattice, the Alg-based materials had high total porosity (>80%). Discrepancies were found between the porosity values reported by the manufacturers and the values obtained in this study. The proposed method is plausible for the systematic characterization of porous biomaterials. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.
A large number of resorbable bone graft substitutes are being marketed as porous, but the total porosity being referred does not take into account many of the biologically important physical aspects of porosity. Therefore, to allow the direct comparison of different commercial products, there is a need to adopt guidelines for a standardized characterization. The aim of the study was to assess a microcomputed tomography-based method for the characterization of porous biomaterials to allow head-to-head comparison of these materials. The study included two commercial biomaterials (Actifuse® and ChronOs® ) and three experimental biomaterials (sintered bioactive glass microspheres, porous alginate (Alg), and porous Alg/hydroxyapatite composite). In addition to porosity and pore size distributions, the interconnectivity of the pores was assessed by an iterative blocking of interconnections. The biomaterials were characterized in their original morphologies (granules or cones). Differences between the materials were demonstrated. Actifuse® had the broadest distributions of pores and interconnections. ChronOs® had a substantial fraction of closed pores (10%). Other materials had closed porosity below 1%. Due to the thinner walls of the lattice, the Alg-based materials had high total porosity (>80%). Discrepancies were found between the porosity values reported by the manufacturers and the values obtained in this study. The proposed method is plausible for the systematic characterization of porous biomaterials. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.
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