The current state of the ecology of the impact regions is outlined. It is argued that the complex of ecosystems situated around a point polluter (an impact region) is an appropriate model for solving several fundamental and applied ecological problems related to the exploration of strong external impacts on biota. Typical methodological errors resulting from insufficient attention to specific features of passive experiments are analysed, and ways to avoid them are proposed. The principles of spatial arrangements of study sites within the impact region and of the selection of experimental and evaluation units are discussed.