A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies
Tekijät: Huang T, Ding M, Bergholdt HKM, Wang TG, Heianza Y, Sun DJ, Frazier-Wood AC, Aslibekyan S, North KE, Voortman T, Graff M, Smith CE, Lai CQ, Varbo A, Lemaitre RN, de Jonge MEAL, Fumeron F, Corella D, Wang CA, Tjonneland A, Overvad K, Sorensen TIA, Feitosa MF, Wojczynski MK, Kähönen M, Renström F, Psaty BM, Siscovick DS, Barroso I, Johansson I, Hernandez D, Ferrucci L, Bandinelli S, Linneberg A, Zillikens MC, Sandholt CH, Pedersen O, Hansen T, Schulz CA, Sonestedt E, Orho-Melander M, Chen TA, Rotter JI, Allison MA, Rich SS, Sorli JV, Coltell O, Pennell CE, Eastwood P, Hofman A, Uitterlinden AG, van Rooij FJA, Chu AY, Rose LM, Ridker PM, Viikari J, Raitakari O, Lehtimäki T, Mikkilä V, Willett WC, Wang YJ, Tucker KL, Ordovas JM, Kilpeläinen TO, Province MA, Franks PW, Arnett DK, Tanaka T, Toft U, Ericson U, Franco OH, Mozaffarian D, Hu FB, Chasman DI, Nordestgaard BG, Ellervik C, Qi L, Ellervik C, Qi L
Kustantaja: AMER ASSOC CLINICAL CHEMISTRY
Julkaisuvuosi: 2018
Journal: Clinical Chemistry
Tietokannassa oleva lehden nimi: CLINICAL CHEMISTRY
Lehden akronyymi: CLIN CHEM
Vuosikerta: 64
Numero: 1
Aloitussivu: 183
Lopetussivu: 191
Sivujen määrä: 9
ISSN: 0009-9147
eISSN: 1530-8561
DOI: https://doi.org/10.1373/clinchem.2017.280701
BACKGROUND: Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined.METHODS: We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene (LCT-13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between (a) dairy intake and BMI, (b) rs4988235 and dairy intake, and (c) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies.RESULTS: Higher dairy intake was associated with higher BMI (beta = 0.03 kg/m(2) per serving/day; 95% CI, 0.00-0.06; P = 0.04), whereas the LCT genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14-0.25) serving/day higher dairy intake (P = 3.15 x 10(-12)) and 0.12 (95% CI, 0.06-0.17) kg/m(2) higher BMI (P = 2.11 x 10(-5)). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (beta = 0.60 kg/m(2) per serving/day; 95% CI, 0.27-0.92; P = 3.0 x 10(-4)).CONCLUSIONS: The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults. (c) 2017 American Association for Clinical Chemistry
