A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based Study
Tekijät: Heli Malm, Alan S. Brown, Mika Gissler, David Gyllenberg, Susanna Hinkka-Yli-Salomäki, Ian W. McKeague, Myrna Weissman, Priya Wickramaratne, Miia Artama, Jay A. Gingrich, Andre Sourander
Kustantaja: Elsevier BV
Julkaisuvuosi: 2016
Lehti: Journal of the American Academy of Child and Adolescent Psychiatry
Vuosikerta: 55
Numero: 5
Aloitussivu: 359
Lopetussivu: 366
Sivujen määrä: 8
ISSN: 0890-8567
eISSN: 1527-5418
DOI: https://doi.org/10.1016/j.jaac.2016.02.013
Abstract
OBJECTIVE:
To investigate the impact of gestational exposure to selective serotonin reuptake inhibitors (SSRIs) on offspring neurodevelopment.
METHOD:
This is a cohort study using national register data in Finland between the years 1996 and 2010. Pregnant women and their offspring were categorized into 4 groups: SSRI exposed (n = 15,729); exposed to psychiatric disorder, no antidepressants (n = 9,651); exposed to SSRIs only before pregnancy (n = 7,980); and unexposed to antidepressants and psychiatric disorders (n = 31,394). We investigated the cumulative incidence of offspring diagnoses of depression, anxiety, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) for the 4 groups from birth to 14 years, adjusting for confounders.
RESULTS:
The cumulative incidence of depression among offspring exposed prenatally to SSRIs was 8.2% (95% CI = 3.1-13.3%) by age 14.9 years, compared with 1.9% (95% CI = 0.9-2.9%) in the psychiatric disorder, no medication group (adjusted hazard ratio [HR] = 1.78; 95% CI = 1.12-2.82; p = .02) and to 2.8% (95% CI = 1.4-4.3%) in the SSRI discontinued group (HR = 1.84; 95% CI = 1.14-2.97; p = .01). Rates of anxiety, ASD, and ADHD diagnoses were comparable to rates in offspring of mothers with a psychiatric disorder but no medication during pregnancy. Comparing SSRI exposed to unexposed individuals, the HRs were significantly elevated for each outcome.
CONCLUSION:
Prenatal SSRI exposure
