Synthesis of oligonucleotide analogues by using phosphoramidite reagents derived from 2,2-bis(hydroxymethyl)malonates



: Guzaev A, Salo H, Azhayev A, Lonnberg H

Publisher: INST ORGANIC CHEM AND BIOCHEM

: 1996

: Collection of Czechoslovak Chemical Communications

: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

: COLLECT CZECH CHEM C

: 61

: S226

: S229

: 4

: 0010-0765


A new family of non-nucleosidic phospharamidite rt agents derived from either esters or amides of 2,2-bis(hydroxymethyl)malonic acid is described. The utility of the building blocks 1-5 ii demonstrated by preparation of 5'-phosphorylated oligonucleotides as well as hydrophobic, polyamino and fluorescent labelled oligonucleotide analogues.



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