A1 Refereed original research article in a scientific journal
Transcriptional profiling of macrophage and tumor cell interactions in vitro
Authors: Roudnicky F, Hollmen M
Publisher: ELSEVIER SCIENCE BV
Publication year: 2016
Journal: Genomics Data
Journal name in source: GENOMICS DATA
Journal acronym: GENOM DATA
Volume: 8
First page : 1
Last page: 3
Number of pages: 3
ISSN: 2213-5960
DOI: https://doi.org/10.1016/j.gdata.2016.02.009
Abstract
Macrophages are important mediators of tumor progression and their function is broadly influenced by different microenvironmental stimuli. To understand the molecular basis of the tumor-supporting role of macrophages in aggressive breast cancer we co-cultured human peripheral monocytes with two breast cancer cell lines representing distinct aggressive cellular phenotype and transcriptionally profiled the changes occurring in both cells during in vitro activated crosstalk. Here we provide a detailed description of the experimental design, sample identity and analysis of the Illumina RNA-Seq data, which have been deposited into Gene Expression Omnibus (GEO): GSE75130. (C) 2016 The Authors. Published by Elsevier Inc.
Macrophages are important mediators of tumor progression and their function is broadly influenced by different microenvironmental stimuli. To understand the molecular basis of the tumor-supporting role of macrophages in aggressive breast cancer we co-cultured human peripheral monocytes with two breast cancer cell lines representing distinct aggressive cellular phenotype and transcriptionally profiled the changes occurring in both cells during in vitro activated crosstalk. Here we provide a detailed description of the experimental design, sample identity and analysis of the Illumina RNA-Seq data, which have been deposited into Gene Expression Omnibus (GEO): GSE75130. (C) 2016 The Authors. Published by Elsevier Inc.
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