A1 Journal article – refereed

Pim-1 kinase and p100 cooperate to enhance c-myb activity

List of Authors: Leverson JD, Koskinen PJ, Orrico FC, Rainio EM, Jalkanen KJ, Dash AB, Eisenman RN, Ness SA

Publisher: CELL PRESS

Publication year: 1998

Journal: Molecular Cell

Journal name in source: MOLECULAR CELL

Journal acronym: MOL CELL

Volume number: 2

Issue number: 4

Number of pages: 9

ISSN: 1097-2765

DOI: http://dx.doi.org/10.1016/S1097-2765(00)80141-0

The pim-1 oncogene is regulated by hematopoietic cytokine receptors, encodes a serine/threonine protein kinase, and cooperates with c-myc in lymphoid cell transformation. Using a yeast two-hybrid screen, we found that pim-1 protein binds to p100, a transcriptional coactivator that interacts with the c-Myb transcription factor. Pim-1 phosphorylated p100 in vitro, formed a stable complex with p100 in animal cells, and functioned downstream of Ras to stimulate c-Myb transcriptional activity in a p100-dependent manner. Thus, pim-1 and p100 appear to be components of a novel signal transduction pathway affecting c-Myb activity, linking all three to the cytokine-regulated control of hematopoietic cell growth, differentiation, and apoptosis.

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