A2 Refereed review article in a scientific journal

MYC AMPLIFICATION - REGULATION OF MYC FUNCTION




AuthorsKOSKINEN PJ, MAKELA TP, VASTRIK I, ALITALO K

PublisherELSEVIER SCIENCE BV

Publication year1993

Journal name in sourceCLINICA CHIMICA ACTA

Journal acronymCLIN CHIM ACTA

Volume217

Issue1

First page 57

Last page62

Number of pages6

ISSN0009-8981

DOIhttps://doi.org/10.1016/0009-8981(93)90237-X


Abstract
The myc oncogenes have been implicated in the control of cell proliferation in both normal and neoplastic cells. There is increasing evidence that Myc proteins function as transcriptional regulators of other genes apparently involved in the control of cell proliferation. The effects of Myc on both gene expression and cell growth are differentially regulated by the recently described Max and DELTAMax proteins that can either cooperate or compete with Myc for sequence-specific DNA binding.



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