A2 Refereed review article in a scientific journal
MYC AMPLIFICATION - REGULATION OF MYC FUNCTION
Authors: KOSKINEN PJ, MAKELA TP, VASTRIK I, ALITALO K
Publisher: ELSEVIER SCIENCE BV
Publication year: 1993
Journal name in source: CLINICA CHIMICA ACTA
Journal acronym: CLIN CHIM ACTA
Volume: 217
Issue: 1
First page : 57
Last page: 62
Number of pages: 6
ISSN: 0009-8981
DOI: https://doi.org/10.1016/0009-8981(93)90237-X
Abstract
The myc oncogenes have been implicated in the control of cell proliferation in both normal and neoplastic cells. There is increasing evidence that Myc proteins function as transcriptional regulators of other genes apparently involved in the control of cell proliferation. The effects of Myc on both gene expression and cell growth are differentially regulated by the recently described Max and DELTAMax proteins that can either cooperate or compete with Myc for sequence-specific DNA binding.
The myc oncogenes have been implicated in the control of cell proliferation in both normal and neoplastic cells. There is increasing evidence that Myc proteins function as transcriptional regulators of other genes apparently involved in the control of cell proliferation. The effects of Myc on both gene expression and cell growth are differentially regulated by the recently described Max and DELTAMax proteins that can either cooperate or compete with Myc for sequence-specific DNA binding.
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