DETERMINATION OF PK VALUES OF GUANOSINE NUCLEOTIDES AND NUCLEOSIDES AND RELATED-COMPOUNDS



: LABADI I, LONNBERG H

Publisher: MAGYAR KEMIA FOLYOIRAT

: 1990

Magyar Kemiai Folyoirat

MAGYAR KEMIAI FOLYOIRAT

: MAGY KEM FOLY

: 96

: 11-12

: 508

: 514

: 7

: 0025-0155


Protonation constants of the N1 atom of the guanine base and of the phosphate group were determined. Increase and corresponding decrease in the basicity of the N1 and phosphate group reflected intermolecular electrostatic interaction for the 5' isomers of the m7-guanosin nucleotides. A correlation has been found between the acid-base properties, conformation and the inhibition properties of these compounds in some kind of protein synthesis.



Last updated on 2025-13-10 at 11:23