B1 Non-refereed article in a scientific journal
DETERMINATION OF PK VALUES OF GUANOSINE NUCLEOTIDES AND NUCLEOSIDES AND RELATED-COMPOUNDS
Authors: LABADI I, LONNBERG H
Publisher: MAGYAR KEMIA FOLYOIRAT
Publication year: 1990
Journal:: Magyar Kemiai Folyoirat
Journal name in source: MAGYAR KEMIAI FOLYOIRAT
Journal acronym: MAGY KEM FOLY
Volume: 96
Issue: 11-12
First page : 508
Last page: 514
Number of pages: 7
ISSN: 0025-0155
Abstract
Protonation constants of the N1 atom of the guanine base and of the phosphate group were determined. Increase and corresponding decrease in the basicity of the N1 and phosphate group reflected intermolecular electrostatic interaction for the 5' isomers of the m7-guanosin nucleotides. A correlation has been found between the acid-base properties, conformation and the inhibition properties of these compounds in some kind of protein synthesis.
Protonation constants of the N1 atom of the guanine base and of the phosphate group were determined. Increase and corresponding decrease in the basicity of the N1 and phosphate group reflected intermolecular electrostatic interaction for the 5' isomers of the m7-guanosin nucleotides. A correlation has been found between the acid-base properties, conformation and the inhibition properties of these compounds in some kind of protein synthesis.
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