A1 Refereed original research article in a scientific journal
The distribution of mitoses in the imaginal disks of third-instar Drosophila melanogaster larvae
Authors: Omel'yanchuk LV, Nokkala C, Mattila J, Lebedeva LI, Baimak TY, Akhmetova KA
Publisher: MAIK NAUKA/INTERPERIODICA/SPRINGER
Publication year: 2007
Journal:: Genetika / Russian Journal of Genetics
Journal name in source: RUSSIAN JOURNAL OF GENETICS
Journal acronym: RUSS J GENET+
Volume: 43
Issue: 7
First page : 769
Last page: 775
Number of pages: 7
ISSN: 1022-7954
DOI: https://doi.org/10.1134/S1022795407070083
Abstract
Development of Drosophila imaginal discs is accompanied by a high-ordered cell proliferation. However, the distinctions in the topographic distribution of mitoses at different developmental stages are insufficiently studied. In this work, we have analyzed the distribution of mitoses in the wing disc of third-instar larvae and determined the regions where mitotic clustering. The results obtained demonstrate that the proliferation rate is region-specific, which is determined by the location of cell cycle regulators and/or the location of growth factors. A comparison of the topography of mitoses with the activity patterns of the regulatory regions of gene string (stg), a known regulator of the mitotic M phase, has demonstrated a similarity between the topography and the activity pattern of one of these regions. The similarity between mitotic distributions in the left and right discs of the same larva (compared with the similarity of gene neuralized expression patterns is considered, and the degree of histone H3 phosphorylation at various mitotic stages is analyzed.
Development of Drosophila imaginal discs is accompanied by a high-ordered cell proliferation. However, the distinctions in the topographic distribution of mitoses at different developmental stages are insufficiently studied. In this work, we have analyzed the distribution of mitoses in the wing disc of third-instar larvae and determined the regions where mitotic clustering. The results obtained demonstrate that the proliferation rate is region-specific, which is determined by the location of cell cycle regulators and/or the location of growth factors. A comparison of the topography of mitoses with the activity patterns of the regulatory regions of gene string (stg), a known regulator of the mitotic M phase, has demonstrated a similarity between the topography and the activity pattern of one of these regions. The similarity between mitotic distributions in the left and right discs of the same larva (compared with the similarity of gene neuralized expression patterns is considered, and the degree of histone H3 phosphorylation at various mitotic stages is analyzed.
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