A1 Refereed original research article in a scientific journal

Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells




AuthorsZlatev HP, Auriola S, Monkkonen J, Maatta JA

PublisherELSEVIER SCIENCE BV

Publication year2016

JournalEuropean Journal of Pharmaceutical Sciences

Journal name in sourceEUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Journal acronymEUR J PHARM SCI

Volume86

First page 58

Last page66

Number of pages9

ISSN0928-0987

eISSN1879-0720

DOIhttps://doi.org/10.1016/j.ejps.2016.02.016(external)


Abstract

Conclusion: Nitrogen containing bisphosphonates require active endocytosis for cellular uptake and in the breast cancer cells the mechanismis uniformly dynamin dependent for all the formulations tested. This differs e.g. from the previous observations on macrophages, which mostly utilize macropinocytosis. Liposomal formulation was found to prolong the duration of the drug effect in cells. (C) 2016 Elsevier B.V. All rights reserved.




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