A1 Refereed original research article in a scientific journal
Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells
Authors: Zlatev HP, Auriola S, Monkkonen J, Maatta JA
Publisher: ELSEVIER SCIENCE BV
Publication year: 2016
Journal: European Journal of Pharmaceutical Sciences
Journal name in source: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Journal acronym: EUR J PHARM SCI
Volume: 86
First page : 58
Last page: 66
Number of pages: 9
ISSN: 0928-0987
eISSN: 1879-0720
DOI: https://doi.org/10.1016/j.ejps.2016.02.016(external)
Conclusion: Nitrogen containing bisphosphonates require active endocytosis for cellular uptake and in the breast cancer cells the mechanismis uniformly dynamin dependent for all the formulations tested. This differs e.g. from the previous observations on macrophages, which mostly utilize macropinocytosis. Liposomal formulation was found to prolong the duration of the drug effect in cells. (C) 2016 Elsevier B.V. All rights reserved.