A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Diurnal rhythms of blood glucose, serum ghrelin, faecal IgA and faecal corticosterone in rats subjected to restricted feeding using the diet board
Tekijät: Iiris Kasanen, Katja Inhilä, Eriika Savontaus, Hanna-Marja Voipio, Kai Õkva, Satu Mering, Vesa Kiviniemi, Jann Hau, Sakari Laaksonen, Timo Nevalainen
Kustantaja: SAGE PUBLICATIONS INC
Julkaisuvuosi: 2018
Journal: Laboratory Animals
Tietokannassa oleva lehden nimi: Laboratory animals
Lehden akronyymi: Lab Anim
Vuosikerta: 52
Numero: 1
Aloitussivu: 29
Lopetussivu: 37
Sivujen määrä: 9
ISSN: 1758-1117
DOI: https://doi.org/10.1177/0023677217709850
Tiivistelmä
Laboratory rats are generally fed ad libitum, although this method is associated with obesity and an increased frequency of spontaneous tumours. It has been challenging looking for ways to limit feed consumption in group-housed rats without any setbacks to animal welfare and scientific results. The diet board, as a method of dietary restriction, was used in the present study. Diet board feeding allows group housing and should result in enhanced welfare compared with traditional methods of dietary restriction. With respect to animal model robustness and translatability of results it is important that the feeding regime does not affect diurnal rhythmicity of biological parameters. In the present study the effects of diet board feeding on diurnal rhythms of blood glucose, serum ghrelin, faecal immunoglobulin A (IgA) and faecal corticosterone were assessed. The diet board did not alter diurnal rhythms, and adds weight to the use of this method for dietary restriction which should benefit animal health and the validity of scientific results generated from the animals.
Laboratory rats are generally fed ad libitum, although this method is associated with obesity and an increased frequency of spontaneous tumours. It has been challenging looking for ways to limit feed consumption in group-housed rats without any setbacks to animal welfare and scientific results. The diet board, as a method of dietary restriction, was used in the present study. Diet board feeding allows group housing and should result in enhanced welfare compared with traditional methods of dietary restriction. With respect to animal model robustness and translatability of results it is important that the feeding regime does not affect diurnal rhythmicity of biological parameters. In the present study the effects of diet board feeding on diurnal rhythms of blood glucose, serum ghrelin, faecal immunoglobulin A (IgA) and faecal corticosterone were assessed. The diet board did not alter diurnal rhythms, and adds weight to the use of this method for dietary restriction which should benefit animal health and the validity of scientific results generated from the animals.
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