A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Plant stanol ester consumption and arterial elasticity and endothelial function
Tekijät: Raltakari OT, Salo P, Gylling H, Miettinen TA
Kustantaja: CAMBRIDGE UNIV PRESS
Julkaisuvuosi: 2008
Lehti: British Journal of Nutrition
Tietokannassa oleva lehden nimi: BRITISH JOURNAL OF NUTRITION
Lehden akronyymi: BRIT J NUTR
Vuosikerta: 100
Numero: 3
Aloitussivu: 603
Lopetussivu: 608
Sivujen määrä: 6
ISSN: 0007-1145
DOI: https://doi.org/10.1017/S0007114508922546
Tiivistelmä
We evaluated whether plant stanol esters mixed with different vegetable oil spreads improved arterial health. A total of 200 adults with serum cholesterol > 5 mmol/l were randomised to consume camelina, rapeseed or sunflower oil spread with stanol (2 g/d) ester or sunflower oil spread without stanol ester (controls) for 3 months. Non-invasive ultrasound was used to measure carotid artery compliance (CAC) and brachial artery flow-mediated endothelial dependent vasodilatation (FMD) at baseline and after the intervention as markers of arterial health. Plant stanol esters reduced LDL-cholesterol by 9 % compared with controls (P < 0.001) similarly in the different treatment groups. In the combined treatment groups (n 147), CAC or FMD were not changed from controls (n 47). In a subgroup analysis, division Of Subjects at baseline into below and over sex-specific 50th percentiles of CAC and FIVID revealed that low CAC was improved from 1.23 to 1.59 % per 10 mmHg in the treatment group (11 69) and from 1.42 to 1.47 % per 10 mmHg in controls (n 25), (P=0.0035 between groups). Low FMD was improved from 6.9 % to 8.6 % in the treatment group (n 73) and from 6.6 % to 6.8 % in controls (n 24) (P=0.05 between groups). In the respective high-median groups, CAC and FMD were not changed in spite of significantly lowered LDL-cholesterol. In conclusion, consumption of plant stanol ester for 3 months had no overall significant effect on arterial elasticity and endothelial function. A controlled study is needed to test whether beneficial changes are obtained in subjects with initially reduced arterial elasticity and endothelial function.
We evaluated whether plant stanol esters mixed with different vegetable oil spreads improved arterial health. A total of 200 adults with serum cholesterol > 5 mmol/l were randomised to consume camelina, rapeseed or sunflower oil spread with stanol (2 g/d) ester or sunflower oil spread without stanol ester (controls) for 3 months. Non-invasive ultrasound was used to measure carotid artery compliance (CAC) and brachial artery flow-mediated endothelial dependent vasodilatation (FMD) at baseline and after the intervention as markers of arterial health. Plant stanol esters reduced LDL-cholesterol by 9 % compared with controls (P < 0.001) similarly in the different treatment groups. In the combined treatment groups (n 147), CAC or FMD were not changed from controls (n 47). In a subgroup analysis, division Of Subjects at baseline into below and over sex-specific 50th percentiles of CAC and FIVID revealed that low CAC was improved from 1.23 to 1.59 % per 10 mmHg in the treatment group (11 69) and from 1.42 to 1.47 % per 10 mmHg in controls (n 25), (P=0.0035 between groups). Low FMD was improved from 6.9 % to 8.6 % in the treatment group (n 73) and from 6.6 % to 6.8 % in controls (n 24) (P=0.05 between groups). In the respective high-median groups, CAC and FMD were not changed in spite of significantly lowered LDL-cholesterol. In conclusion, consumption of plant stanol ester for 3 months had no overall significant effect on arterial elasticity and endothelial function. A controlled study is needed to test whether beneficial changes are obtained in subjects with initially reduced arterial elasticity and endothelial function.
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