Refereed journal article or data article (A1)

Biological activity of ellagitannins: Effects as anti-oxidants, pro-oxidants and metal chelators

List of Authors: Moilanen J, Karonen M, Tahtinen P, Jacquet R, Quideau S, Salminen JP

Publisher: Pergamon-Elsevier Science LTD

Publication year: 2016

Journal: Phytochemistry

Journal name in source: PHYTOCHEMISTRY

Journal acronym: Phytochemistry

Volume number: 125

Number of pages: 8

ISSN: 0031-9422



Ellagitannins are a subclass of hydrolysable tannins that have been suggested to function as defensive compounds of plants against herbivores. However, it is known that the conditions in the digestive tracts of different herbivores are variable, so it seems reasonable to anticipate that the reactivities and modes of actions of these ingested defensive compounds would also be different. A previous study on a few ellagitannins has shown that these polyphenolic compounds are highly oxidizable at high pH and that their bioactivity can be attributed to certain structural features. Herein, the activities of 13 ellagitannins using the deoxyribose assay were measured. The results provided information about the anti-oxidant, pro oxidant and metal chelating properties of ellagitannins. Surprisingly, many of the tested ellagitannins exhibited pro-oxidant activities even at neutral pH and only moderate to low radical scavenging activities, although the metal chelating capacities of all tested ellagitannins were relatively high. (C) 2016 Elsevier Ltd. All rights reserved.

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