A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

Mammary analog secretory carcinoma of minor palatal salivary glands: A case report and review of the literature




TekijätTessa Helkamaa, Sami Rossi, Karri Mesimäki, Anni Suomalainen, Jussi Tarkkanen, Ilmo Leivo, Alena Skalova, Jaana Hagström

KustantajaELSEVIER SCIENCE INC

Julkaisuvuosi2015

JournalJournal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Vuosikerta27

Numero5

Aloitussivu698

Lopetussivu702

Sivujen määrä5

ISSN2212-5558

eISSN2212-5566

DOIhttps://doi.org/10.1016/j.ajoms.2015.02.005


Tiivistelmä

Mammary analog secretory carcinoma (MASC) is a recently described entity of malignant salivary gland tumors that histologically resembles mammary secretory carcinoma (SC) of the breast. MASC was earlier often categorized as an unusual variant of salivary acinic cell carcinoma (AciCC) or adenoid cystic carcinoma (ADCC). According to the literature, MASC is most often found in the major salivary glands, and it has been suggested to metastasize more often than AciCC. Here, we present the first case of MASC occurring in minor salivary glands of the hard palate, including diagnosis, treatment, and follow-up. Diagnosis was based on histomorphological and immunohistochemical findings and on a specific translocation of the ETV6 gene on chromosome 12p13. Differential diagnosis excluded AciCC, ADCC, cribriform cystadenocarcinoma, and polymorphous low-grade adenocarcinoma. Radiological, resection, and immunohistological findings are presented with radiological and clinical pictures. In our patient, neck dissection was not performed, and during the 18-month follow-up no recurrence or metastasis was found. Despite all the MASC cases described in the literature, standardized treatment protocols are still lacking.



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