A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Mammary analog secretory carcinoma of minor palatal salivary glands: A case report and review of the literature
Tekijät: Tessa Helkamaa, Sami Rossi, Karri Mesimäki, Anni Suomalainen, Jussi Tarkkanen, Ilmo Leivo, Alena Skalova, Jaana Hagström
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2015
Journal: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Vuosikerta: 27
Numero: 5
Aloitussivu: 698
Lopetussivu: 702
Sivujen määrä: 5
ISSN: 2212-5558
eISSN: 2212-5566
DOI: https://doi.org/10.1016/j.ajoms.2015.02.005
Mammary analog secretory carcinoma (MASC) is a recently described entity of malignant salivary gland tumors that histologically resembles mammary secretory carcinoma (SC) of the breast. MASC was earlier often categorized as an unusual variant of salivary acinic cell carcinoma (AciCC) or adenoid cystic carcinoma (ADCC). According to the literature, MASC is most often found in the major salivary glands, and it has been suggested to metastasize more often than AciCC. Here, we present the first case of MASC occurring in minor salivary glands of the hard palate, including diagnosis, treatment, and follow-up. Diagnosis was based on histomorphological and immunohistochemical findings and on a specific translocation of the ETV6 gene on chromosome 12p13. Differential diagnosis excluded AciCC, ADCC, cribriform cystadenocarcinoma, and polymorphous low-grade adenocarcinoma. Radiological, resection, and immunohistological findings are presented with radiological and clinical pictures. In our patient, neck dissection was not performed, and during the 18-month follow-up no recurrence or metastasis was found. Despite all the MASC cases described in the literature, standardized treatment protocols are still lacking.