A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Brain Docosahexaenoic Acid [DHA] Incorporation and Blood Flow Are Increased in Chronic Alcoholics: A Positron Emission Tomography Study Corrected for Cerebral Atrophy
Tekijät: Umhau JC, Zhou W, Thada S, Demar J, Hussein N, Bhattacharjee AK, Ma K, Majchrzak-Hong S, Herscovitch P, Salem N, Urish A, Hibbeln JR, Cunnane SC, Rapoport SI, Hirvonen J
Kustantaja: PUBLIC LIBRARY SCIENCE
Kustannuspaikka: SAN FRANCISCO; 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
Julkaisuvuosi: 2013
Journal: PLoS ONE
Tietokannassa oleva lehden nimi: Plos One
Lehden akronyymi: PLoS One
Numero sarjassa: 10
Vuosikerta: 8
Numero: 10
Sivujen määrä: 7
ISSN: 1932-6203
eISSN: e75333
DOI: https://doi.org/10.1371/journal.pone.0075333
Objective: Chronic alcohol dependence has been associated with disturbed behavior, cerebral atrophy and a low plasma concentration of docosahexaenoic acid (DHA, 22:6n-3), particularly if liver disease is present. In animal models, excessive alcohol consumption is reported to reduce brain DHA concentration, suggesting disturbed brain DHA metabolism. We hypothesized that brain DHA metabolism also is abnormal in chronic alcoholics. Methods: We compared 15 non-smoking chronic alcoholics, studied within 7 days of their last drink, with 22 non-smoking healthy controls. Using published neuroimaging methods with positron emission tomography (PET), we measured regional coefficients (K*) and rates (J(in)) of DHA incorporation from plasma into the brain of each group using [1-C-11]DHA, and regional cerebral blood flow (rCBF) using [O-15]water. Data were partial volume error corrected for brain atrophy. Plasma unesterified DHA concentration also was quantified. Results: Mean K* for DHA was significantly and widely elevated by 10-20%, and rCBF was elevated by 7%-34%, in alcoholics compared with controls. Unesterified plasma DHA did not differ significantly between groups nor did whole brain J(in), the product of K* and unesterified plasma DHA concentration. Discussion: Significantly higher values of K* for DHA in alcoholics indicate increased brain avidity for DHA, thus a brain DHA metabolic deficit vis-a-vis plasma DHA availability. Higher rCBF in alcoholics suggests increased energy consumption. These changes may reflect a hypermetabolic state related to early alcohol withdrawal, or a general brain metabolic change in chronic alcoholics.
