A1 Refereed original research article in a scientific journal

Long-term test-retest reliability of striatal and extrastriatal dopamine D-2/3 receptor binding: study with [C-11]raclopride and high-resolution PET




AuthorsAlakurtti K, Johansson JJ, Joutsa J, Laine M, Backman L, Nyberg L, Rinne JO

PublisherNATURE PUBLISHING GROUP

Publication year2015

JournalJournal of Cerebral Blood Flow and Metabolism

Journal name in sourceJOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Journal acronymJ CEREBR BLOOD F MET

Volume35

Issue7

First page 1199

Last page1205

Number of pages7

ISSN0271-678X

eISSN1559-7016

DOIhttps://doi.org/10.1038/jcbfm.2015.53


Abstract

We measured the long-term test-retest reliability of [C-11]raclopride binding in striatal subregions, the thalamus and the cortex using the bolus-plus-infusion method and a high-resolution positron emission scanner. Seven healthy male volunteers underwent two positron emission tomography (PET) [C-11]raclopride assessments, with a 5-week retest interval. D-2/3 receptor availability was quantified as binding potential using the simplified reference tissue model. Absolute variability (VAR) and intraclass correlation coefficient (ICC) values indicated very good reproducibility for the striatum and were 4.5%/0.82, 3.9%/0.83, and 3.9%/0.82, for the caudate nucleus, putamen, and ventral striatum, respectively. Thalamic reliability was also very good, with VAR of 3.7% and ICC of 0.92. Test-retest data for cortical areas showed good to moderate reproducibility (6.1% to 13.1%). Our results are in line with previous test-retest studies of [C-11]raclopride binding in the striatum. A novel finding is the relatively low variability of [C-11]raclopride binding, providing suggestive evidence that extrastriatal D-2/3 binding can be studied in vivo with [C-11]raclopride PET to be verified in future studies.




Last updated on 2024-26-11 at 22:22